59489-71-3, name is 2-Amino-5-bromopyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Amino-5-bromopyrazine
Step 4: A solution of 2-amino-5-bromopyrazine (600 mg, 3.45 mmol), tetrakis(triphenyl-phospine)palladium(0) (186 mg, 0.17 mmol) and NaSCH3 (490 mg, 7 mmol) in DMF (20 mL) was warmed at 60 C. overnight in a sealed tube. The reaction mixture was poured onto water and aqueous NaHCO3 and extracted 3 times into CH2Cl2/ether. The combined organic phase was washed with saturated NaCl, dried over Na2SO4 and concentrated in vacuo. Purification by chromatography (silica, 0-20% ethyl acetate/hexanes gradient) afforded 5-methylsulfanyl-pyrazin-2-ylamine (305 mg, 63%): 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 2.52 (s, 3H) 4.48 (br. s., 2H) 7.91 (d, J=1.51 Hz, 1H) 7.98 (d, J=1.51 Hz, 1H).
The synthetic route of 59489-71-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Brotherton-Pleiss, Christine E.; Walker, Keith A. M.; US2012/149718; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem