Related Products of 5521-58-4, These common heterocyclic compound, 5521-58-4, name is 5-Methylpyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
l-Chloro-N,N-2-trimethylpropenylamine (0.08 mL, 0.60 mmol) was added to a solution of 3 – { [5-(azetidin- 1 -ylcarbonyl)-3 -chloropyridin-2-yl] oxy } -5 – { [2-fluoro- 1 – (fluoromethyl)ethyl]oxy}benzoic acid (215 mg, 0.5 mmol) in DCM (5 mL) and the reaction stirred at RT for 30 – 40 minutes. Pyridine (0.08 mL, 1.0 mmol) and 2-amino-5- methylpyrazine (108 mg, 1.0 mmol) were added and the reaction stirred for 16 hours before being concentrated in vacuo and water (20 mL) added. The mixture was extracted with ethyl acetate (3 x 20 mL), washed with IN hydrochloric acid (20 mL), a saturated solution of sodium hydrogen carbonate (20 mL), brine (20 mL), dried (MgSO4) and concentrated in vacuo. The crude product was chromatographed on silica, eluting with a gradient of 0-10% methanol in DCM, to give the desired compound as a white solid (150 mg). 1H NuMR delta (CDCl3): 2.40 (quintet, 2H), 2.56 (s, 3H), 4.22-4.31 (m, 2H), 4.32-4.40 (m, 2H), 4.62 – 4.82 (m, 5H), 7.06 (t, IH), 7.38 (t, IH), 7.47 (t, IH), 8.15 (s, IH), 8.17 (s, IH), 8.25 (d, IH), 8.46 (s, IH), 9.55 (s, IH); m/z 518 (M+H)+, 516 (M-H)”
The synthetic route of 5521-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/7041; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem