Some common heterocyclic compound, 15707-23-0, name is 2-Ethyl-3-methylpyrazine, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H10N2
EXAMPLE II Preparation Of (R,S)-2-(2-Hydroxy-2-phenylethyl)-3-ethylpyrazine A reaction of 2-ethyl-3-methylpyrazine (12.2 g, 0.01 mole) with benzaldehyde (10.6 g, 0.1 mole) is conducted in accordance with the procedure of Example I. Workup followed by bulb-to-bulb distillation (155C oven/0.02 mm Hg) provides 18.2 g of a light yellow colored oil. This material crystallizes on trituration with hexane, giving 17.80 g (78%) of desired product, mp 52-53C. An analytical sample is obtained by recrystallization from hexane: mp 53-54C; 1H NMR (CDCl3) delta 1.25 (t, 3H, J = 7.4 Hz), 2.77 (q, 2H, J = 7.4 Hz), 3.16 (d, 2H, J = 6.2 Hz), 5.01 (d, 1H, J = 2.5 Hz), 5.28 (m, 1H), 7.27-7.46 (m, 5H), 8.33 (d, 1H, J = 2.8 Hz), 8.40 (d, 1H, J = 2.8 Hz). Anal. Calc. for C14H16N2O: C,73.65; H,7.06; N,12.27 Found: C,73.73; H,7.01; N,12.31
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15707-23-0, its application will become more common.
Reference:
Patent; Philip Morris Products Inc.; EP309203; (1990); A3;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem