Application of 27825-20-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27825-20-3 as follows.
3-Hydroxypyrazine-2-carboxylic acid methyl ester (1 g, 6.49 mmol, 1 eq.) Was added to a suspension of sodium hydride (60%, 259 mg, 6.49 mmol, 1 eq.DMF (50 mL). The reaction solution was stirred at room temperature for 1 h and then (3,3-dimethoxycyclobutyl) methylmethanesulfonate(1.46 g, 6.49 mmol, 1 eq.) Was added and the mixture was stirred at 130 & lt; 0 & gt; C for 18 h. After completion of the reaction, the mixture was diluted with 50 mL of waterThe mixture was extracted with EtOAc (60 mL x 2) and the organic phase was washed with saturated sodium chloride solution (60 mL x 2), dried over anhydrous sodium sulfate,Filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 3/1) to give the title compound as a white solid(220 mg, 54%).
According to the analysis of related databases, 27825-20-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd. of Guangdong; Ren, Qingyun; Luo, Huichao; Tang, Changhua; Zhang, Jiancun; Zhang, Yingjun; (30 pag.)CN104447583; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem