Application of 153800-11-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 153800-11-4 name is 2-Ethynylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 18i(i00m, 03i9mmol) and 10(66.5mg, 0.639mmo1) in 2OmL of Et3N wasadded Pd(PPh3)2C12 (11.21mg, 0Oi6mmoi) and CuT (608mg, 0O32mmoi). The mixture wasprotected with N: atmosphere, then was heated at 70C for 4 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-i-IPLC to give the target product Compound 111(18mg, yield: 1948%).LCMS: rn/z 290 (M¡ÀH) +?H NMR (400 MHz, CDCI3): 5 8.84 (d, J 1.6 Hz, 1H), 8.63-8.62 (rn, IH), 8.55 (d, J= 2.4 Hi, 111) 97 (d 1 2 S Hi III) 7 8 (t, 1H? 7 79 (d 1 9 2 hi ill) 4- 2 (in, 111), 6.83 (d, J:::: 2.4 Hz, IH),
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethynylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem