4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines
Example 10: Pyratzetajne-2,3-dicarboxylic arid mono-((3S,4aR,6aR,6bS,8aS, 11S, 12aR, 14aR, 14bS)-11-methoxycarbonyl-4,4,6a,6b,8a, 11, 14b-heptamethyl-14-oxo-1 ,2,3,4,4a, 5, 6,6a,6b,7, 8, 8a,9, 10, 1 1, 12, 12a, 14, 14a, 14b-icosahydro-picen-3-yl) ester (YP034JGlycyrrhetinic acid methyl ester (1.0 g, 2.0 mmol) was stirred in toluene (25 ml) and 2,3-pyrazine-dicarboxylic anhydride (1.7 g, 11.5 mmol) added. The mixture was heated at 110C for 16-20 hours. After cooling, the mixture was added to water (200 ml) and extracted into /-propyl acetate (3 x 70 ml), which was dried (MgSO4) and concentrated to give the crude adduct. Purification was effected using silica chromatography (eluent: 0-10% methanol in DCM) to give the title compound as a yellow solid (500 mg). LCMS purity 90.5% (633 = [M-H] ).1H NMR (400MHz, CDCl3) delta 8.78 (IH, br), 8.70 (IH, br), 5.68 (IH, s) 4.88 (IH, dd, J = 11.6Hz, 4.8Hz), 3.62 (3H, s), 2.80 (IH, br d), 2.35 (IH, s), 2.1-0.6 (4OH, m).
The synthetic route of 4744-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YORK PHARMA PLC; WO2007/105015; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem