Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H6N2O
General procedure: 1.0 eq. ethyl (2R)-2-acetoxy-3-(2-hydroxyphenyl)propanoatc (Preparation 3aa-(R)), 2.0eq. of the appropriate alcohol and 2.0 eq. triphenylphosphine were dissolved in dry toluene(0.2 M for the phenol), then 2.0 eq. di-tert-butyl azodicarboxylate was added. The mixturewas stirred at 50C under nitrogen. After reaching an appropriate conversion the volatileswere removed under reduced pressure, the crude intermediate was purified via flash chromatography using heptane / EtOAc as cluents.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6705-33-5, its application will become more common.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem