Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2423-65-6, name is Pyrazine 1-oxide, A new synthetic method of this compound is introduced below., Recommanded Product: Pyrazine 1-oxide
General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.2-(3-Methoxyphenyl)pyrazine N-oxide (Table 4, Entries 6 and 7) Synthesised according to general procedure 2. Purification via silica gel column chromatography using 100% DCM then a mixture of 15% Acetone/DCM gave a white solid, 72% with 2 eq. of the N-oxide and 84% yield with 3 eq. of the N-oxide). 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.63 (1H, s), 8.38 (1H, d, J=3.9 Hz), 8.20 (1H, d, J=4.2 Hz), 7.46-7.29 (3H, m), 7.05 (1H, dd, J=1.8 and 8.4 Hz), 3.85 (3H, s). 13C NMR (75 MHz, CDCl3, 293K, TMS): 159.4, 148.3, 145.5, 144.3, 134.4, 130.0, 129.6, 121.3, 116.2, 114.4, 55.3.
The synthetic route of 2423-65-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; University of Ottawa; US2008/132698; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem