These common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Pyrazines
General procedure: A mixture of 4-(2-aminoethyl)benzenesulfonamide (0.5 g,2.5 mmol), anhydrous sodium acetate (0.41 g, 5.0 mmol) and anacid anhydride (2.5 mmol) was stirred in glacial acetic acid(15 mL). The mixture was heated under reflux for 12 h and thereaction was monitored with the help of TLC. After completion ofreaction the solvent was removed under reduced pressure andthe crude solid obtained was washed with water, dried and recrystallisedfrom an appropriate solvent.
The synthetic route of 2,3-Pyrazinecarboxylic anhydride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Abdel-Aziz, Alaa A.-M.; Angeli, Andrea; El-Azab, Adel S.; Abu El-Enin, Mohamed A.; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 25; 5; (2017); p. 1666 – 1671;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem