Adding a certain compound to certain chemical reactions, such as: 98-97-5, name is Pyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98-97-5, category: Pyrazines
To a solution of pyrazine-2-carboxylic acid (1 g, 8.06 mmol) in DMF (5 mL), 4-methyl-3-thiosemicarbazide (933 mg, 8.87 mmol) was added. DIPEA (2.5 mL, 14.5 mmol) was added drop-wise at RT, then the mixture was cooled in an ice-bath before adding T3P (50% w/wEtOAc) (7.1 mL, 12.09 mmol). The reaction was stirred at RT on. NaOH 4 M solution (7.5mL) was added (resulting pH=8). The reaction was diluted with EtOAc and the two resulting phases were separated (the upper organic layer eliminated). The pH was increased to 11 NaOH 4and the mixture heated to 70 C for 2h. The yellow solution was then cooled in an ice bath and 37% HC1 was slowly added till pH 5. A precipitate formed. It was filtered under vacuum, washed with water and Cy and dried to obtain 1.44 g of title compound (p20, y%92). MS(m/z): 194.1 [MH]t
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Reference:
Patent; INDIVIOR UK LIMITED; CREMONESI, Susanna; MICHELI, Fabrizio; SEMERARO, Teresa; TARSI, Luca; (318 pag.)WO2017/21920; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem