Related Products of 4949-13-7, A common heterocyclic compound, 4949-13-7, name is 2-Fluoropyrazine, molecular formula is C4H3FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 8. Preparation of 4,5,6, 7-tetrahydro-5-(5-methoxypyridin-3-yl)-Lambda/-(pyrazin-2- yl)thiazolo[5,4-c]pyridin-2-amine (Compound 18)[00121] As shown in step 8-i of Scheme 8, to a solution of 5-(5-methoxypyridin-3-yl)- 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine (Compound 1026, 20 mg, 0.076 mmol) in NMP (1 mL) was added 2-fluoropyrazine (22.4 mg, 0.229 mmol) and Cs2CO3 (149 mg, 0.46 mmol). The reaction mixture was heated 110 0C for 18 h. The crude mixture was purified by medium pressure silica gel chromatography (0 to 10% MeOH in DCM) followed by a second purification using reversed-phase chromatography (5 to 90 % CHsCN/water). Fractions containing pure produce were brought to a neutral pH and the product isolated as the bis-HCl salt to give 4,5,6,7-tetrahydro-5-(5-methoxypyridin-3-yl)-Lambda/-(pyrazin-2-yl)thiazolo[5,4- c]pyridin-2-amine (Compound 18, 4 mg): ESMS (M+H) 341.13; 1H NMR (CD3OD, 300MHz) delta 8.65 (d, J=I.5 Hz, IH), 8.51 (t, J= 1.5Hz, IH), 8.41 (d, J=2.7Hz, IH), 8.22 (d, J=2.4 Hz, 1H),7.96 (d, J=2.4 Hz, 1H),7.69 (t, J=2.4 Hz, IH), 4.67 (s, 2H), 4.04 (s, 3H), 3.98 (t, J=5.7 Hz, 2H), 3.01 (t, J=5.7 Hz, 2H) ppm.
The synthetic route of 4949-13-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; BANDARAGE, Upul, Keerthi; COTTRELL, Kevin; DAVIES, Robert; KRUEGER, Elaine; LEDEBOER, Mark; LEDFORD, Brian; LE TIRAN, Arnaud; LIAO, Yusheng; MESSERSMITH, David; WANG, Tiansheng; XU, Jinwang; WO2010/96389; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem