Adding a certain compound to certain chemical reactions, such as: 5780-66-5, name is Pyrazine-2-carbaldehyde, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5780-66-5, Recommanded Product: Pyrazine-2-carbaldehyde
EXAMPLE 28 To a suspension of 4 g of 5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one in 70 ml of dimethyl sulphoxide are added, with stirring and under cover of nitrogen, 3.9 g of 2-pyrazinecarboxaldehyde and, after cooling to 19¡ã C., 1.6 g of 60percent sodium hydride are added portionwise while maintaining the reaction medium at a temperature between 15¡ã and 21¡ã C. The stirring is continued for 4 hours and then 70 ml of water, 5 ml of acetic acid and 50 ml of methanol are successively added dropwise at a temperature in the region of 20¡ã C. The suspension obtained is filtered and the solid thus isolated is washed with methanol, air-dried and triturated in a mixture of 80 ml of dimethylformamide and 25 ml of methanol. After drying at 60¡ã C. under vacuum (1 mmHg; 0.13 kPa) 3.3 g of 10-(2-pyrazinylmethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are obtained, in the form of a red-orange solid melting above 260¡ã C. (Analysis percent calculated C: 69.00, H: 3.54, N: 22.35, O: 5.11, percent found C: 69.6, H: 3.6, N: 22.0, O: 4.9).
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Reference:
Patent; Rhone-Poulenc Rorer S.A.; US5753657; (1998); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem