Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Recommanded Product: 870787-06-7
PREPARATION EXAMPLE 7: 3-trifluoromethyl-pyrazine-2-carboxylic acid ri-(5-bromo-3-50 mg of C-[1 -(5-bromo-3-chloro-pyridin-2-yl)-cyclopropyl]-methylamine (step 1 of PREPARATION EXAMPLE 2) was dissolved in 0.9 ml of dichloromethane and 0.085 ml of triethylamine was added at ambient temperature. Then 383 mg of 3- (trifluoromethyl)pyridine-2-carboxylic acid, 54 mg of HOBT hydrate, 76 mg of EDCI.HCI and 37 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid were added sequentially. The reaction mixture was stirred at ambient temperature for 14 hours and then water was added, the phases were separated and the aqueous phase was extracted withdichloromethane. The organic phases were combined, dried with anhydrous sodium sulphate, filtered and concentrated. Crude material was obtained as a yellow sticky solid, which was purified by flash chromatography on silica gel with cyclohexane/ethyl acetate (1 :1 ) as a solvent. Thus, 76 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid [1 -(5-bromo- 3-chloro-pyridin-2-yl)-cyclopropylmethyl]-amide was obtained as a sticky solid. . 1H-NMR (CDCIs): 8.80 ppm (s, 1 H), 8.75 ppm (s, 1 H), 8.65 ppm (s, 1 H), 7.95 ppm (s, 1 H), 7.70 ppm (m, 1 H), 3.72 ppm (d, 2H), 1 .18 ppm (m, 4H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; PITTERNA, Thomas; LOISELEUR, Olivier; WORTHINGTON, Paul, Anthony; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; BOBOSIK, Vladimir; WO2013/64521; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem