In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57948-41-1, name is 3-Bromoimidazo[1,2-a]pyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H4BrN3
A round bottom flask was charged with 12a (250 mg, 0.86 mg), 3-bromoimidazo[1,2-a]pyrazine (255 mg, 1.29 mmol), Pd(PPh3)2Cl2 (30 mg, 0.043 mmol), CuI (16 mg, 0.086 mmol). 80 mL dry DMF and DIPEA (333 mg, 2.58 mmol) were added to the flask and the solution was degassed with argon for 5 min. The solution was stirred under argon atmosphere at 80 C for 18 h. The reaction solution was filtered through Celite and the solvent was removed by rotary evaporation to get crude mixture. The crude mixture was purified with silica gel column chromatography (MeOH/DCM, v/v = 1/100) to provide Mthyl 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzoate (160 mg, 0.55 mmol) as light yellow solid, yielded 64%. 1H NMR (400 MHz, DMSO-d6) delta 9.20 (s, 1H), 8.81 (dd, J1 = 4.4 Hz, J2 = 1.2 Hz), 8.23 (s, 1H), 8.12 (d, J = 4.4 Hz), 8.06 (s, 1H), 7.85 (s, 1H), 7.82 (s, 1H). LC-MS (ESI) m/z 292 [M + H] +.
The synthetic route of 57948-41-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Cui, Shengyang; Wang, Yongjin; Wang, Yuting; Tang, Xia; Ren, Xiaomei; Zhang, Lei; Xu, Yong; Zhang, Zhang; Zhang, Zhi-Min; Lu, Xiaoyun; Ding, Ke; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 470 – 482;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem