Adding a certain compound to certain chemical reactions, such as: 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122-05-4, SDS of cas: 122-05-4
9.35 g (167 mmol) of potassium hydroxide and 11 g (65 mmol) of 2,5-pyrazinedicarboxylic acid (3) were dissolved in water (200 ml). To this solution, 5% Pd / C catalyst was added at a rate of 5 mol% with respect to the reaction substrate, hydrogen (1 MPa) was supplied while heating to 50 C.And the hydrogenation reaction was carried out for 18 hours. It was confirmed with a gas chromatograph that raw materials were consumed and the reaction proceeded quantitatively. An aqueous solution of the product was obtained by filtering the reaction solution to remove the catalyst. This product has a measurement result obtained by 1 H NMR measurement in the reference (Witichemistry described in J. Med. Chem. 1985, 28, 1228-1234), ak, DT; Nair, RV; Schmid, FA, “Synthesis and antimetastatic properties of stereoisomeric tricyclic bis (dioxopiperazines) in the Lewis lung carcinoma model” By agreement with the shift value, it was confirmed that it was 2,5-piperazine dicarboxylic acid (4).
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Reference:
Patent; IHI Corporation; Waseda University; Sato, Yutaka; Kanomata, Norihiro; Yuchi, Takeshi; (19 pag.)JP2018/140981; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem