In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6966-01-4 as follows. Recommanded Product: Methyl 3-amino-6-bromopyrazine-2-carboxylate
Example 10 : 3-Amino-6-anilino-N-(2-methoxyphenyl)pyrazine-2-carboxamide(Compound II-3)SCHEME XCompound 11-3METHOD J:Step 1: 3-Amino-6-anilino-pyrazine-2-carboxylic acid[00167] Methyl 3-amino-6-bromo-pyrazine-2-carboxylate (1 g, 4.310 mmol) , aniline (401.4 mg, 392.8 mu, 4.310 mmol), sodium t-butoxide (952.7 mg, 9.913 mmol), Pd2(dba)3 (197.3 mg, 0.2155 mmol) and DavePhos (84.81 mg, 0.2155 mmol) were taken into toluene (10 mL) and heated at reflux under an atmosphere of nitrogen. The reaction mixture was cooled to ambient temperature and partitioned between EtOAc/saturated aqueous aHC03. The resultant precipitate was isolated by filtration and the aqueous layer extracted with EtOAc (x 3). The aqueous layer was acidified with 1M HCl and the resultant precipitate was isolated by filtration and combined with the previous precipitate to give the sub-title product as a beige solid (337 mg, 34% Yield). ‘H NMR (400.0 MHz, DMSO) delta 6.83 (t, 1H), 7.21- 7.25 (m, 2H), 7.69 (d, 2H), 8.10 (s, 1H), 9.07 (s, 1H) ppm; MS (ES+) 231.0.
According to the analysis of related databases, 6966-01-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; KNEGTEL, Ronald, Marcellus, Alphonsus; O’DONNELL, Michael; REAPER, Philip, Michael; WO2011/143419; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem