Electric Literature of 313339-92-3, A common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
11482] 1 -Methyl-34(2R,3R)-2-methylpiperidin-3-yl)tet- rahydropyrimidin-2(1H)-one (404, 120 mg, 0.55 mmol) was dissolved in 10 mE DMF. To it were added 3,5-dichioropy- razine-2-cabonitrile (175 mg, 1.0 mmol) and DIEA (350 pL, 2.0 mmol). The mixture was stirred at RT for 30 mM, diluted with 150 mE EtOAc, washed with water x3, dried, concentrated in vacuo, and subjected to silica flash colunm using 0 to 3.5% MeOH in DCM to isolate 3-chloro-5-((2R,3R)-2-me- thyl-3-(3-methyl-2-oxotetrahydropyrimidin-i (2H)-yl)pip- eridin-i-yl)pyrazine-2-carbonitrile (405, 60mg, 31% yield).
The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem