Related Products of 5521-55-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of the corresponding acid (1.0 to 2.0 equiv) and amine (1.0 equiv) in CH2CI2 was added DIPEA (3.0 equiv). HBTU (2.0 equiv) was added at 0 C. The resulting mixture was stirred at r.t. for 24 h. The reaction mixture was diluted with CH2CI2 and washed with water. The organic layer was separated and dried over anhydrous Na2SO4. The solution was concentrated to give a crude product, which was purified with a silica gel column (EtOAc/hexane) to obtain the desired product.
The synthetic route of 5-Methylpyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; NEAMATI, Nouri; ZHOU, Jia; KUANG, Yuting; YE, Na; (130 pag.)WO2016/187544; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem