Application of 109-08-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-08-0 as follows.
Step 1: 2-Chloromethylpyrazine To a solution of 2-methylpyrazine (4.7 g) in carbon tetrachloride (200 mL) were added N-chlorosuccinimide (8 g) and benzoyl peroxide (0.6 g). The mixture was brought to reflux with two 150-watt spotlights and irradiated for 4.5 hours. The mixture was then cooled to room temperature, evaporated to dryness, and chromatographed on flash silica gel using a mixture of ethyl acetate:toluene (1:4) as eluant to give the title compound as an oil, which was stored at 78¡ã C. as a solid. 1 H NMR (Ace-d6): delta 4.8 (2H, s), 8.6 (2H, s), 8.8 (1H, s).
According to the analysis of related databases, 109-08-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Merck Frosst Canada, Inc.; US5389650; (1995); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem