Reference of 16298-03-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16298-03-6 name is Methyl 2-aminopyrazine-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(A) Methyl 2-bromo-3-pyrazine carboxylate: To a stirred mixture of 12.7 g. of methyl 2-amino pyrazine carboxylate and 47 ml. of 48percent hydrobromic acid there was added, dropwise, 12.6 ml. of bromine keeping the temperature at 0¡ã. A solution of 14.4 g. of sodium nitrite in 60 ml. of water was then added, dropwise, at 0¡ã and the reaction mixture stirred for 15 minutes. The reaction mixture was basified to pH 8 with sodium bicarbonate and extracted with ethyl acetate and again with chloroform. The organic layers were dried over magnesium sulfate, filtered and concentrated to a yellow oil. Recrystallization from ether-hexane yielded the product, m.p. 43¡ã-45¡ã C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-aminopyrazine-3-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Schering Corporation; US4680297; (1987); A;; ; Patent; Schering Corporation; US4680298; (1987); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem