Synthetic Route of 6705-33-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6705-33-5 as follows.
To a mixture of 5-[4-(trifluoromethoxy)phenyl]-3H-l,3-benzoxazol-2-one (100 mg, 0.34 mmol), pyrazin-2-ylmethanol (111.9 mg, 1.02 mmol) and PPh3 (177.7 mg, 0.68 mmol) in THF (6 mL) was added the DIAD (136.99 mg, 0.68 mmol) at 0 C and the mixture was stirred under N2 at 20 C for 16 hours to give the mixture. The mixture was concentrated to dryness, diluted with H20 (10 mL), and extracted with EtOAc (10 mL chi 2). The combined organic phase was washed with brine (10 mL), dried over Na2SC>4, filtered and the filtrate was concentrated to give the crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 0% to 35% to 45% to 60%) to give the product (100.9 mg, 260.4 muiotaetaomicron, 77% yield) as an oil. *H NMR DMSO-< 400MHz deltaH = 8.83 (s, 1H), 8.60 - 8.53 (m, 2H), 7.74 (d, 2H), 7.63 (s, 1H), 7.50 - 7.42 (m, 4H), 5.35 (s, 2H). LCMS Rt = 1.52 min in 2 min chromatography, MS ESI calcd. for C19H13F3N3O3 [M+H]+ 388.1, found 388.1.
According to the analysis of related databases, 6705-33-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PRAXIS PRECISION MEDICINES , INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (244 pag.)WO2018/148745; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem