In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54608-52-5 as follows. HPLC of Formula: C4H6N4
General procedure: Sodium (0.70 g, 30.44 mmol) was dissolved in 50 mL of anhydrous ethanol, and 2-chloro-6-hydrazinylpyrazine (2a) (4.00 g, 27.67 mmol) was added. The reaction solution was heated to 60 C until the mixture was totally dissolved. Keep the temperature of the reaction below 40 C, and diethyl maleate (4.77 g, 27.67 mmol) was added dropwise. The reaction was heated to 45 C and cooled to room temperature after 5 h. The reaction was quenched with glacial acetic acid (1.83 g, 30.44 mol) and stirred for 1 h. The resulting solution was evaporated in vacuo, dissolved in 50 mL of water, extracted with CH2Cl2 (3¡Á50 mL). The extracts was washed with brine, dried with anhydrous MgSO4 and evaporated to give the crude product, which was further purified with recrystallization (diehyl ether) as a yellow solid, 4.25 g.
According to the analysis of related databases, 54608-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Liu, Weijie; Li, Jiao; He, Kai; Huang, Fangfang; Ma, Yi; Li, Yuxin; Li, Qingshan; Xu, Fengbo; Chinese Chemical Letters; (2019); p. 417 – 420;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem