These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Chloropyrazine
Step 1: tert-Butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate Into a 1 L flask equipped with a condenser and a magnetic stir bar was added 2-chloropyrazine (20.6 g, 180 mmol), tert-butyl piperazine-1-carboxylate (33.5 g, 180 mmol), potassium carbonate (29.8 g, 216 mmol), dioxane (225 mL) and DMF (225 mL). The mixture was heated to 120 C. for 3 days. The mixture was cooled and poured into a 1 L separatory funnel containing brine (600 mL) and extracted with Et2O (3*200 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification by column chromatography through silica gel, eluting with 50:50 hexanes:EtOAc to 20:80 hexanes:EtOAc as a gradient, afforded the title compound as a yellow solid.
The synthetic route of 2-Chloropyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem