Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Methylpyrazine-2-carboxylic acid
5-methyl-2-pyrazinecarboxylic acid (122 mg, 0.88 mmol),CDI (143 mg, 0.88 mmol),DMAP (108 mg, 0.88 mmol)Was dissolved in anhydrous dichloromethane (10 mL)Nitrogen protection, the reaction at room temperature for 2 hours.Betulin amine (200 mg, 0.44 mmol) was added to the above reaction solution to continue the reaction for 8 hours.After completion of the TLC detection reaction, the solvent was removed under reduced pressure,The mixture was extracted with H2O (30 mL) and extracted with ethyl acetate (20 mL ¡Á 3). The combined organic phases were dried over anhydrous Na2SO4, concentrated and purified by silica gel column chromatography(DCM: MeOH = 20: 1) to give a white solid (205 mg, 81%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China Normal University; Qiu Wenwei; Yi Zhengfang; Liu Mingyao; Cui Haiwei; He Yuan; Wang Jinhua; Yang Lianfang; Gao Cheng; (22 pag.)CN104744549; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem