Synthetic Route of 122-05-4,Some common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, molecular formula is C6H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
After dissolving 76.8 mmol of I2 in 70 ml of pyridine, was added to a 250 ml three-necked flask and heated to 100 C under a nitrogen atmosphere, A solution of 120 ml of pyridine (completed in 4 hours) containing 27.41 mmol of 2,5-dicarboxylic acid pyrazine was slowly added dropwise, After completion of the dropwise addition, heating was continued for 2 hours, cooled, filtered and washed with 50 ml of ether to give a brown powder solid. The powder solids were then placed in a round bottom flask and 150 ml of methanol was added, heated to reflux for 1 h, cooled, filtered, Followed by washing with 40 ml of methanol and 40 ml of diethyl ether to give a brown powder as an intermediate 2,5-dicarboxylic acid pyrazine pyridinium iodide.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2,5-dicarboxylic acid, its application will become more common.
Reference:
Patent; Zhengzhou University of Light Industry; LI, XILI; ZHOU, LIMING; LI, CAIFENG; GAO, LIJUN; FANG, SHAOMING; (15 pag.)CN103896972; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem