Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde, A new synthetic method of this compound is introduced below., category: Pyrazines
4,4-Difluoropiperidine hydrochloride [CAS RN: 144230-52-4] (495 mg, 3.14 mmol,1.6 eq), 5-chloropyrazine-2-carbaldehyde [CAS RN: 88625-24-5] (280 mg,3.14 mmol, 1.0 eq) and sodium triacetoxyborohydride (1.32 g, 6.29 mmol,3.2 eq) were suspended in 17 mL 1,2-dichloroethane. Then, triethylamine (0.55mL, 3.93 mmol, 2.0 eq) was added and the reaction mixture was stirred at rtovernight. Then, water was added and the resulting phases were separated bythe use of a Whatman filter. The volatile components of the organic phase wereremoved in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane/ethyl acetate 9/1 -> hexane/ethyl acetate 1/1) to give 320mg (63% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.56 mm; MS (EI0): m/z = 248 [M+H].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem