98-97-5, name is Pyrazine-2-carboxylic acid, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C5H4N2O2
General procedure: The N-hydroxysuccinimideesters of pyrazinecarboxylic acid and (5)-(+)-ibuprofen were prepared by dissolving the starting acid (0.200 g, 1.0 equiv) in dry tetrahydrofuran. With stirring at 0 C, NHydroxysuccinimide (1.0 equiv) was added followed by N,N-dicyclohexylcarbodiimideequiv). The mixture was warmed to ambient temperature and stirred for 24 h. The N,Ndicyclohexylurea was removed by filtration and the filtrate was concentrated to afford a solid that was purified by column chromatography.[001481 2, 5-Dioxopyrrolidin-1-yl pyrazine-2-carboxylate 14. The cmde white solid was purified by column chromatography (Si02, acetone/dichloromethane, 1:4) to give a white solid (0.2757 g, 77%). Mp: 161 – 164 C. ?H NMR (300 MHz, CDC13): oe 9.40 (d, J= 1.41H), 8.90 (d, J= 2.3 Hz, 1H), 8.83 (dd, J= 2.4, 1.5 Hz, 1H), 2.95 (s, 4H). ?3C NMRMHz, CDC13): oe 168.9, 159.6, 149.3, 147.1, 145.2, 140.2, 25.8. JR (neat): 3501, 3324, 3276, 3078, 2929, 2851, 1875, 1806, 1785, 1703, 1653, 1626, 1571, 1533, 1468, 1449, 1420, 1399, 1360, 1306, 1260, 1243, 1203, 1183, 1153, 1075, 1060, 1048, 1025, 1011, 995,892, 876, 853, 811, 782, 764, 713 cmi. HRMS calcd. for C9H8N304 [M+Hj 222.0509, found 222.0502.
The synthetic route of 98-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY; PIRRUNG, Michael, C.; BAKAS, Nicole, A.; BACHMANN, Andre; (89 pag.)WO2017/156471; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem