109-08-0, name is 2-Methylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 109-08-0
To a solution of 2- methylpyrazine (20.0 g, 212 mmol) in 1,4-dioxane (140 ml) was added ethyl 2-oxoacetate (56.4 g, 276 mmol) and diacetoxyiron (0.99 g, 6.4 mmol) under N2. The reaction was heated at 140¡ãC for 48 h. The mixture was concentrated under reduced pressure. The residue was purified by FCC (0 – 10percent EtOAc / petroleum ether) to give the title compound. Y = 30 percent. .H NMR (400 MHz, chloroform-;/) delta 8.54 – 8.48 (m, 3H), 4.70 – 4.64 (m, 1H), 4.26 (q, J= 8 Hz, 2H), 3.38 – 3.33 (m, 1H), 3.25 – 3.19 (m, 1H), 1.26 (t, J= 7 Hz, 3H).
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem