Application of 313339-92-3, These common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(4-tert-butoxycarbonyl-aminophenyl) boronic acid pinacol ester (8.26 g) was added to a reaction vessel containing a magnetic stirrer in 3,5-dichloro-pyrazine-2-carbonitrile (5.0 g), 1,1 ‘-bis (diphenylphosphino) ferrocene-palladium (II) dichloride (1.68 g) and cesium carbonate (28.1 g) followed by 100 ml of dioxane and 10 ml of water were added and the mixture was heated to 100 C. with stirring.After 1 h, the reaction mixture was cooled to room temperature and then quenched with saturated sodium bicarbonate solution (100 ml) and extracted with EtOAc (3 ¡Á 200 ml) The combined organic phases were dried over sodium sulfate, The product was purified by flash chromatography on a silica gel using a mixture of EtOAc and heptane as the eluant and the product was recrystallized from methyl tert-butyl ether to give the crude product as a brown oil which was purified by flash chromatography After drying in vacuo, tert-butyl ester of [4- (6-chloro-5-cyano-pyrazin-2-yl) -phenyl] -carbamic acid was obtained as a pale yellow solid. 6.92 g (73%)
Statistics shows that 3,5-Dichloropyrazine-2-carbonitrile is playing an increasingly important role. we look forward to future research findings about 313339-92-3.
Reference:
Patent; SANOFI; NAZARE, MARC; HALLAND, NIS; SCHMIDT, FRIEDEMANN; WEISS, TILO; DIETZ, UWE; HOFMEISTER, ARMIN; CARRY, JEAN-CHRISTOPHE; (93 pag.)JP5827849; (2015); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem