These common heterocyclic compound, 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromo-5H-pyrrolo[2,3-b]pyrazine
2-bromo-5H-pyrrolo[2,3-b]pyrazine (6.5g, 32.82 mmol), (4- isopropylsulfonylphenyl) boronic acid (7.859 g, 34.46 mmol) and palladiumtriphenylphosphane complex (1.896 g, 1.641 mmol) were combined in a round bottomed flask. To this mixture was added dioxane (97.50 mL) and then an aqueous solution of Na2C03 (49.23 mL of 2 M, 98.46 mmol). The resulting suspension was stirred at 100 C overnight, then heating was stopped and water added. The resultant precipitate was collected and dried in vacuo at 40C, to give the sub-title compound as a brown solid (9.45 g, 95% yield). XH NMR (400.0 MHz, DMSO) d 12.25 (s, 1H), 9.00 (s, 1H), 8.43 (d, J = 8.4 Hz, 2H), 7.99 – 7.96 (m, 3H), 6.74 (d, J = 3.5 Hz, 1H), 3.57 (s, 1H) and 1.20 (d, J = 6.8 Hz, 6H) ppm; MS (ES+) 435.2
The synthetic route of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; EVERITT, Simon; MORTIMORE, Michael, Paul; CHARRIER, Jean-damien; MACCORMICK, Somhairle; STORCK, Pierre-henri; KNEGTEL, Ronald; PINDER, Joanne; DURRANT, Steven; WO2012/178124; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem