20721-17-9, name is 5-Methylpyrazin-2(1H)-one, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines
2-HYDROXY-5-METHYLPYRAZINE (0.984g, 8.94 mmol) was refluxed in 15 mL PHOSPHOROXY- chloride for 1.5h. The reaction mixture was slowly poured into ice and adjusted to pH6 by addition of sodium carbonate. The mixture was extracted six times with ethyl acetate (50 mL each). The combined organic extracts were dried with sodium sulfate, filtered and eva- porated. The crude product was used without any further purification for the next step.
The synthetic route of 20721-17-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/80998; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem