Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Quality Control of (3-Chloropyrazin-2-yl)methanol
Under nitrogen protection,To a solution of 3-chloro-2-pyrazine methanol (60 g, 414.9 mmol)Triphenylphosphine (130.4 g, 497.9 mmol)And phthalimide (73.2 g, 497.9 mmol)Of the 500 mL THF solution,Was slowly added dropwise at -5 DIAD (100.6g, 497.9mmol),After complete addition, the reaction mixture was stirred at 20 3h,TLC shows that after completion of the reaction,Water was added to the reaction mixture and then extracted with EA (1 L x 3)The organic phase was dried sufficiently with anhydrous Na2SO4,After evaporation in vacuo, the residue was purified by flash chromatography (PE / EA = 30/1)To give 90.8 g of the title compound
The synthetic route of 89283-32-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chengdu Beite Pharmaceutical Co., Ltd.; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Li Yingfu; Huang Haoxi; Liu Guanfeng; Chen Tonghun; Ren Junfeng; Su Zhonghai; (96 pag.)CN106831787; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem