Adding a certain compound to certain chemical reactions, such as: 22047-25-2, name is Acetylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22047-25-2, Formula: C6H6N2O
General procedure: A 100 mL round-bottom flask charged with 2-acetylpyrazine (1.47 g, 2 mmol) was added MeOH (30 mL), KOH pellets (0.675 g,2 mmol) and water (2 mL). The resulting mixture was stirred for10 min and then added corresponding n,n?-dimethoxybenzaldehydes (1.0 g, 1 mmol) and ammonium solution (6 mL) was added slowly stirring at room temperature for 4 h, a white precipitate obtained was filtered, washed with MeOH and diethyl ether. The crude products on recrystallization in a mixture of CHCl3:MeOH (1:1) gave white crystals of desired compounds, 1-4. 2,2?-[4-(2,3-dimethyoxyphenyl)pyridine-2,6-diyl]dipyrazine(1): Yield: 65%; M.P.: 212 C; 1H NMR (400 MHz, CDCl3, delta ppm): 3.737 (s, 3H, OCH3), 3.945 (s, 3H, OCH3), 7.041e7.045 (d, 1H, ArHC4),7.114e7.119 (d, 1H, ArHC6), 7.134e7.165 (t, 1H, ArHC5), 8.635-8.650(t, 4H, pz, HAA’5,6), 8.683 (s, 2H, pz, HAA’3), 9.869-9.871 (s, 2H, py,HB3,5); 13C{1H} NMR (100 MHz, CDCl3, delta ppm): 153.84 (C2,6 of py),151.02 (C4 of py), 148.73 (C3,30 of pz), 144.58 (C6,60 of pz), 143.57(C5,50 of pz), 133.59 (C6 of ph), 122.11 (C1 of ph), 122.04 (C3,5 of py),110.77 (C5 of ph), 101.31 (C3 of ph), 61.06 (OCH3), 55.08 (OCH3); FTIR (KBr disc, nu cm-1): 2965 (w), 1739 (s), 1588 (m), 1465 (s), 1415(m), 1365 (s), 1270 (s), 1220 (m), 1109 (s), 1053 (s), 1003 (s), 852 (s),786 (s).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Golla, Ramesh; Kumar, P. Raghavendra; Suchethan; Foro, Sabine; Nagaraju; Journal of Molecular Structure; vol. 1201; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem