Adding a certain compound to certain chemical reactions, such as: 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486424-37-7, category: Pyrazines
The 3-(lH-benzimidazol-2-yl)-5-bromopyrazin-2-amine used as a starting material was prepared as follows :-etaATU (7.3 g) was added to a mixture of 3-amino-6-bromopyrazine-2-carboxylic acid (4 g), 1,2-phenylenediamine (2.07 g), triethylamine (3.8 ml) and DMF (40 ml) and the reaction mixture was stirred at ambient temperature for 1 hour. The resultant mixture was poured into aqueous sodium hydrogen carbonate solution and the resultant precipitate was isolated. The material so obtained was dissolved in acetic acid (20 ml) and heated to 900C for 3 hours. The resultant mixture was evaporated and the residue was triturated under methylene chloride. There was thus obtained 3-(lH-benzimidazol-2-yl)-5-bromopyrazin-2-amine (2.7 g); NMR Spectrum: (DMSOd6) 7.29 (m, 2eta), 7.59 (d, IH), 7.76 (d, IH), 8.28 (s, IH), 13.05 (s, IH); Mass Spectrum: M-HH+ 292; RT 2.34 min.
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Reference:
Patent; ASTRAZENECA AB; WO2009/7390; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem