Synthetic Route of 25710-18-3, The chemical industry reduces the impact on the environment during synthesis 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, I believe this compound will play a more active role in future production and life.
To a stirred solution of 4.5 g of compound 3 (22.5 mmol) in 10 mL of acetonitrile, 2.5 mL of phenylacetylene (23.0 mmol), 25 mL of triethylamine (TEA; 180 mmol), 500 mg of palladium(II) acetate (2.2 mmol), 419 mg of copper iodide (2.2 mmol), and 577 mg of triphenylphosphine (2.2mmol) were added, and the mixture was heated up to 80 ¡ãC for 3 h. The resulting mixture was concentrated, dried under vacuum, and extracted with a mixture of EtOAc and water.The organic layer was separated, washed with water, and dried over MgSO4. After the removal of the solvent by a rotary evaporator, the residue was purified by column chromatography using (EtOAc: n-hexane = 1:4) to achieve compound 4 as a yellow solid with 68percent yield
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloropyrido[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Park, Jeong Hoon; Kim, Heejung; Kim, Dong-Yeon; Yang, Seung Dae; Hur, Min Goo; Kim, Sang Wook; Yu, Kook Hyun; Bulletin of the Korean Chemical Society; vol. 36; 7; (2015); p. 1778 – 1783;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem