Adding a certain compound to certain chemical reactions, such as: 98-97-5, name is Pyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98-97-5, COA of Formula: C5H4N2O2
To a solution containing 2-pyrazine carboxylic acid (10 g, 80.5 mmol) in dichloromethane (150 mL) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC (18.5 g, 96.6 mmol) and 1-hydroxybenzotriazole HOBT (13.05 g, 96.6 mmol) and the resulting solution stirred at 25 C. for 30 minutes. Then 1-cyclohexylglycine methyl ester (16.7 g, 80.5 mmol) and Hunig’s base (31.24 g, 241 mmol) was added and the reaction mixture stirred for 2 hours. The reaction mixture was partitioned between water and dichloromethane. The organic layer was removed and dried over MgSO4, filtered and concentrated in vacuo and purified via flash chromatography using ethyl acetate/hexane (20/80 to 30/70) to give a foam (13.3 g, 60%). The product of the previous reaction (6.54 g, 24 mmol) was dissolved in ethanol and treated with 1N sodium hydroxide (35.4 mL, 35.3 mmol) at 25 C. for 4 hours. The mixture was neutralized with 10% HCl to pH 4 and extracted with dichloromethane. The organic layer was removed and dried over MgSO4, filtered and concentrated in vacuo to afford a foam (5 g, 81%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Abbott Laboratories; US2010/29686; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem