Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 6-Chloropyrazine-2-carboxylic acid
Example 25; N-(tert-Butyl)-6-chloropyrazine-2-carboxamide Thionyl chloride (1 mL, 13. 7 mmol) was added to a suspension of the acid (325 mg, 2 mmol) in toluene (5 mL). A drop of DMF was then added and after stirring at RT for 10 min. the mixture was heated at reflux for lh. The reaction was cooled to RT and toluene and excess thionyl chloride were removed under reduced pressure. Toluene (1 mL) was then added to the residue and this was removed under reduced pressure. This process was repeated, and then CtiCIz (10 mL) was added and the resulting solution cooled to QC. t-Butylamine (0. 45 mL, 4.3 mmol) and triethylamine (1.1mL, 8.0 mmol) were then added and the solution stirred at RT overnight. The solution was diluted with 10 mL) and H20 (10 mL) and the organic layer collected and washed with aq. Na2CA and then dried (Na2SO4). The solvent was removed in vacuo and flash chromatography of the residue using CH2Cl2-MeOH (95: 5) separated the pure product as an oil (290 (at) mg, 68 %).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CYTOPIA RESEARCH PTY LTD; WO2005/66156; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem