Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
A compound (1), (2.0 g, 21.0 mmol and 1.0 eq.), and THF (25 ml) were put in and stirred to the 200 ml three necked flask under a nitrogen atmosphere. Next, what dissolved N-bromosuccinimide (8.2 g, 46.1 mmol, 2.2 eq.) in THF (25 ml) was dropped by 0 C, and it agitated for 20 minutes at the room temperature.Cerite filtration of the impurity was carried out after ending reaction. And washed the filtrate by extraction, H2O, and sat.NH4Cl aq. with ethyl acetate, and it was made to dry by Na2SO4, and condensed. a part of obtained residue silica gel column chromatography (7 : n-hexane: eluate : ethyl acetate = 3) separation refinement condensing object compound (2) (3.16 g, yield:60 %) It obtained as a white solid.
According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KEIO UNIVERSITY; SUZUKI, KOJI; CITTERIO, DANIEL; KAKUDATE, YOSHIKI; HOSHINO, EMI; NISHIHARA, RYO; (21 pag.)JP2016/50296; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem