Synthetic Route of 313339-92-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
11360] tert-l3utyl (2R,3R)-2-methylpiperidin-3-ylcarbam- ate (310) (1.1 g, 5.1 mmol) was dissolved in THF (20 mE).the stirred solution was added DIEA (1.34 mE, 7.7 mmol), followed by 3,5-dichloropyrazine-2-cabonitrile (1.07 g,mmol). The reaction was stirred at room temperature forhout An additional amount of 3,5-dichioropyrazine-2-carbo- nitrile (200 mg, 1.2 mmol) was added, and the reaction was stirred for another hour. The solvent was removed under reduced pressure, and the residue was suspended in EtOAc. The organic mixture was washed with iN HC1 (aq), saturated NaHCO3(aq) and brine, dried, and concentrated in vacuo. The residue was then purified by silica flash column chromatography (EtOAc/hexanes) to give tert-butyl (2R,3R)-1 -(6- chioro-5-cyanopyrazin-2-yl)-2-methylpiperidin-3-ylcar- bamate (311), (1.54 g, 4.38 mmol, 86% yield).
The synthetic route of 3,5-Dichloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JIA, Zhaozhong J.; CHEN, Wei; THOMAS, William D.; US2015/158865; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem