Synthetic Route of 4744-50-7, A common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, molecular formula is C6H2N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of 3,4,5-trimethoxyaniline (1.83 g, 10 mmol) and acid anhydride (10 mmol) in glacial acetic acid (15 mL) was heated under reflux for 12 h. After the evaporation of the reaction mixture to dryness under reduced pressure, the residue was neutralized by a solution of sodium bicarbonate (4%) until effervescence ceased. The precipitate obtained was washed with water, dried (P2O5) and recrystallized from an appropriate solvent.
The synthetic route of 4744-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Abdel-Aziz, Alaa A.-M.; Eltahir, Kamal E.H.; Asiri, Yousif A.; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1648 – 1655;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem