Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344940-70-1, name is 5-Bromo-3-phenylpyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
To a solution of 5-bromo-3-phenylpyrazin-2-amine (26 mg, 0.1 mmol) and tert-butyl isopropyl(5-(tributylstannyl)thiazol-2-yl)carbamate (80 mg, 0.15 mmol) in DMF (0.4 mL) was added PdCl2(PPh3)2 (7 mg, 0.01 mmol) followed by DIPEA (0.044 mL, 0.25 mmol) and the reaction heated at 85 0C for 18h. The reaction mixture was cooled to room temperature and diluted with EtOAc (6 mL) and water (2 mL). the layers were separated and the aqueous layer further extracted with EtOAc. The combined organic extracts were dried (Na2SO4), filtered, and concentrated in vacuo. The product was isolated via column chromatography (SiO2, 25% EtO Ac/heptane) to afford the product (44 mg, 100% yield)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344940-70-1.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/155388; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem