Related Products of 95-89-6,Some common heterocyclic compound, 95-89-6, name is 3-Chloro-2,5-dimethylpyrazine, molecular formula is C6H7ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 17: 2 5-dimethVL-3-94-(phenylmethyl) piperazin-1-VLLpyrazine 3-Chloro-2, 5-dimethylpyrazine (1.0 g, 7.0 MMOL) and N-benzylpiperazine (3.7 ML, 21.0 MMOL) were mixed under nitrogen and heated to 125 C for 18 h. Saturated aqueous sodium hydrogen carbonate was added and the product was extracted with chloroform. The combined organic extracts were dried (NA2SO4) and concentrated in vacuo to give a yellow oil. The crude product was purified by flash chromatography using silica gel eluting with methanol : chloroform (2.5 : 97.5) to give the pure product as a yellow oil (1.14 g, 58%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-2,5-dimethylpyrazine, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/72086; (2004); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem