Synthetic Route of 95-58-9, The chemical industry reduces the impact on the environment during synthesis 95-58-9, name is 2-Chloro-3-methylpyrazine, I believe this compound will play a more active role in future production and life.
EXAMPLE 3; 7-r (3R)-3-Amino-4-(2s45-trifluorophenyl) butanoyll-8-methyl-3-(trifluoromethyl) 5, 6, 7, 8-tetrahydro-1, 2, 4-triazolof4, 3-alpyrazine, trifluoroacetate salt; Step A. 2-Hydrazino-3-methylpyrazine; To 15 mL of hydrazine hydrate at ambient temperature was added dropwise 5 g (42.9 mmol) of 2-chloro-3-methylpyrazine. The resultant mixture was heated to 120 C for 45 min then cooled in a refrigerator for 48 h. The yellow precipitate was collected by vacuum filtration and dried under vacuum to give 1.6 g (30%) of the title compound which was used without further purification. 1H NMR (400 MHz, CD30D) 8 7.94 (d, 1H, J=3.0 Hz), 7.63 (d, 1H, J=3.0 Hz), 2.32 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3-methylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2003/82817; (2003); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem