In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312736-50-8 as follows. Computed Properties of C5H3Cl2N3O
107261 To a solution of 3,5-dichloropyrazine-2-carboxamide (Example 12, Step 2, 52 g, 0.27 mol) in acetonitrile (1 L) was added POC13 (146 g, 89 mL, 0.95 mol) at room temperature. The mixture was heated to 90-100 C for 4 h. The mixture was cooled to room tempetature and poured slowlyinto a vigorously stirring solution of saturated aq. NaHCO3. Evolution of gas was observed. The mixture was extracted with EtOAc (3 x). The combined organic layers were dried over sodium sulfate then concentrated under reduced pressure to give a residue. The residue was purified by silica gel chromatography (0-30% EtOAc in hexanes) to give the title compound as a pale yellow solid. ?H NIVIR (400 MHz, CDC13): ppm 8.64 (s, 1H): ?3C NMR (101 IVIFIz, CDC13) ppm 150.8,150.43, 143.24, 128.06, 113.06.
According to the analysis of related databases, 312736-50-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FLX BIO, INC.; BECK, Hilary, Plake; BIANNIC, Berenger; BUI, Minna Hue, Thanh; HU, Dennis, X.; KETCHAM, John, Michael; POWERS, Jay, Patrick; REILLY, Maureen, Kay; ROBLES-RESENDIZ, Omar; SHUNATONA, Hunter, Paul; WALKER, James, Ross; WUSTROW, David, Juergen; YOUNAI, Ashkaan; ZIBINSKY, Mikhail; (396 pag.)WO2018/22992; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem