Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H4ClN3
To a solution of 8.-chioroimidazo[i ,2a1pyrazine (200 mg, I .3 mmol) in MeCN/DCE (3 mL/1,5 mL) was added N1S (293 mg, I .3 mmol) at RT. The mixture was refluxed overnight. TLC (50% EtOAc in petroleum ether) indicated that starting material disappeared, the mixture was poured into water (10 mL), extracted with EtOAc (10 mL x 3). The combined organic layerwas washed with water (1 0 mL) and brine (1 0 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the title compound (200 mg) as a brown solid, LRMS m/z (M-f-H) 279.1, 281.1 found, 279.1, 281.1 required.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem