Related Products of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General procedure: The corresponding substituted salicylanilide 2 (1 mmol) and 5-chloropyrazine-2-carboxylic acid 1 (1 mmol) were dissolved in dryDMF (8 mL), the solution was cooled to 10 C and DCC (1.2 mmol)was added in three portions during 1 h. The mixture was stirred foradditional 3 h at the same temperature and then stored at 4 C for20 h. The precipitate of N,N0-dicyclohexylurea was removed byfiltration and the solvent was evaporated in vacuo till dryness. Thecrude products 3 were purified by one or repeated crystallizationfrom ethyl acetateehexane mixture. 4.1.4.1 4-Chloro-2-{[4-(trifluoromethyl)phenyl]carbamoyl}phenyl 5-chloropyrazine-2-carboxylate (3a) White solid; yield: 35%; mp: 163.4-165.0 C. IR (ATR): 3372 (NH), 3081, 2934, 2857, 1751 (C=O ester), 1663, 1648, 1633, 1600, 1530, 1520, 1477, 1411, 1323, 1297, 1274, 1259, 1190, 1163, 1125, 1104, 1066, 1020, 879, 839, 826, 786, 715, 702, 668. 1H NMR (500 MHz, DMSO-d6): delta 9.40 (1H, bs, NH), 9.23 (1H, d, J = 1.4 Hz, H3″), 8.69 (1H, d, J = 1.4 Hz, H5″), 8.13 (1H, d, J = 2.6 Hz, H3), 7.78 (2H, d, J = 8.4 Hz, H3′, H5′), 7.61 (2H, d, J = 8.3 Hz, H2′, H6′), 7.57 (1H, dd, J = 2.5 Hz, J = 8.6 Hz, H5), 7.52 (1H, d, J = 8.7 Hz, H6); 13C NMR (126 MHz, CDCl3): delta 161.43, 160.35, 154.25, 146.70, 146.04, 144.31, 140.76, 139.71, 132.72, 131.40, 127.46, 126.66 (q, J = 32.8 Hz), 126.19 (q, J = 3.8 Hz), 123.93 (q, J = 272.6 Hz), 123.92, 120.45. MSmonoisotopic (calc/meas): 455.0/455.2; Anal. Calcd. for C19H10ClF3N3O3 (456.20): C, 50.02; H, 2.21; N, 9.21; Found: C, 50.34; H, 2.45; N, 9.43.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Baranyai, Zsuzsa; Kratky, Martin; Vin?ova, Jarmila; Szabo, Nora; Senoner, Zsuzsanna; Horvati, Kata; Stola?ikova, Ji?ina; David, Sandor; Bosze, Szilvia; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 692 – 704;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem