Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28643-16-5, name is Methyl 3-amino-5-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 28643-16-5
Preparation of (S)-(2-(3-chlorobenzyl)pyrrolidin-1-yl)(3-hydroxy-5-phenylpyrazin-2-yl)methanone (9-10); Step 1: Methyl 3-amino-5-chloropyrazine 2-carboxylate 9-6 (1.48 g, 7.89 mmol), phenylboronic acid (1.06 g, 8.68 mmol) and 2M aqueous sodium carbonate (15.8 mL) were mixed with toluene (12 mL) and methanol (3 mL). Palladium tetrakis(triphenylphosphine) (0.9 g, 0.97 mmol) was added. The mixture was degassed and heated under nitrogen at 85 C. for 4 h. The reaction mixture was cooled to room temperature and filtered through a pad of Celite. The filtrate was concentrated to give a mixture with compounds 9-7 and 9-8. The mixture (0.76 g) was suspended in THF (20 mL) and CH3CN (20 mL), and treated with a solution diazomethane trimethylsilane (2.0 M in ether, 2.3 mL, 4.6 mmol). The resulting solution was stirred at room temperature for 1 h, and concentrated in vacuo. The residue was purified by column chromatography (silica gel, gradient elution with 1% MeOH-DCM to 2% MeOH-DCM) to give the desired product 9-8.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CHENG, CLIFFORD; SHIPPS, JR., GERALD W.; HUANG, XIAOHUA; HUANG, YING; SHAO, NING; RAO, ASHWIN; PALANI, ANANDAN; ORTH, PETER; VOIGT, JOHANNES H.; HERR, ROBERT J.; ROSSITER, LANA MICHELE; ZENG, QI; SUN, XIANFENG; US2012/122837; (2012); A1;,
Pyrazine – Wikipedia,
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