In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1094070-46-8 as follows. Formula: C8H9N3S
Part D: To a DMF (400 mL) solution of compound from Example 1 , Part C (21.8 g) was added N-iodosuccinimide (26.9 g) and the resulting mixture was heated overnight at 6OC. The mixture was concentrated and water (400 mL) was added. After stirring 1 hr at rt, saturated sodium carbonate was added (250 mL) and subsequently stirred an additional 30 min at rt. The mixture was filtered, washed with water, methanol (100 mL) and the filter cake was dried overnight under vacuum. A brown solid was obtained (31.4 g, 87%).
According to the analysis of related databases, 1094070-46-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; ALBANY MOLECULAR RESEARCH, INC.; WO2009/97233; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem