In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59489-39-3 as follows. HPLC of Formula: C5H4N4
To a solution of 6-aminopyrazine-2-carbonitrile (l .Og, 8.33mmol, l .Oeq) in acetonitrile (0.5mL) was added N-Bromosuccinimide (2.22g, 12.50mmol,I .5eq). The reaction was stirred at room temperature for 12h. After completion of reaction, reaction mixture was transferred in water and extracted with ethyl acetate. Combined organic layer was washed with brine, dried over sodium sulphate and concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography using 20percent ethyl acetate in hexane to obtain pure 151.1 (0.75g, 45.27percent). MS(ES): m/z 200.01 [M+H]+
According to the analysis of related databases, 59489-39-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem