Reference of 19745-07-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19745-07-4 as follows.
Step F: (S)-3 -(2-fluoro-4-(5-methyl- 1 ,3 ,4-oxadiazol-2-yl)phenoxy)- 1 -(piperidin-4-yl)pyrrolidin-2-one 2,2,2-trifluoroacetate (150 mg, 0.316 mmol) was dissolved in DMSO (3 mL) and 2,5-dichloropyrazine (70.7 mg, 0.474 mmol) and N-ethyl-N- isopropylpropan-2-amine (138 mu, 0.790 mmol) were added and the reaction heated to 100 ¡ãC overnight. The reaction was cooled and diluted with water, extracted with EtOAc, washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified twice over silica gel (100percent EtOAc) to afford (S)-l-(l-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro- 4-(5-methyl-l,3,4-oxadiazol-2-yl)phenoxy)pyrrolidin-2-one (15.2 mg, 0.0321 mmol, 10.2percent yield) as a red solid. Mass spectrum (apci) m/z = 473.1 (M+H).
According to the analysis of related databases, 19745-07-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENCSIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald Jay; PRATT, Scott Alan; SINGH, Ajay; TURNER, Timothy M.; WO2011/146335; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem